One challenge not reflected in the score (though not insurmountable, I trust) is that the fixed media, which occupies something of its own sonic plane in the piece, may at times present something of a distraction (which in context, echoes the turmoil in Macbeth's soul, I think.) I believe that full rehearsals will be the key to getting you accustomed. You will draw steadier and more reliable pitch info from the live quartet.
Later on Saturday, I sent parts out to the instrumentalists.
The play, of course, is the tragedy of a man who sets aside his honor, and indeed sheds his conscience, in order to further his ambition, strewing death all about him in the process.
It cannot be denied that Shakespeare speaks to every age.